免疫原
Synthesized peptide derived from human CAR16 AA range: 101-151
特异性
This antibody detects endogenous levels of CAR16 at Human
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
function:Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.,induction:Down-regulated in patients suffering of Huntington disease.,similarity:Contains 1 CARD domain.,subunit:Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2.,tissue specificity:Widely expressed. Expressed at higher level in placenta, spleen, lymph
基因名称（Gene Name）
CARD16 COP COP1
Fields
>>NOD-like receptor signaling pathway
组织表达
Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
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