免疫原
Synthesized peptide derived from human PDLI3 AA range: 251-301
特异性
This antibody detects endogenous levels of PDLI3 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012],
功能
disease:Quantitative or qualitative alterations of expression have not been detected in facioscapulohumeral muscular dystrophy (FSHD).,function:May play a role in the organization of actin filament arrays within muscle cells.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Localizes to myofiber Z-lines.,subunit:Interacts with ACTN2.,tissue specificity:Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.,
基因名称（Gene Name）
PDLIM3 ALP
细胞定位
Cytoplasm, myofibril, sarcomere, Z line . Localizes to myofiber Z-lines.
组织表达
Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
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