免疫原
Synthesized peptide derived from human SUMO2 AA range: 45-95
特异性
This antibody detects endogenous levels of human SUMO2
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
功能
function:Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.,online information:SUMO protein entry,PTM:Cleavage of precursor form by SENP1 or SENP2 is necessary for function.,PTM:Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.,PTM:Polymeric chains can be formed through Lys-11 cross-linking.,similarity:Belongs to the ubiquitin family. S
基因名称（Gene Name）
SUMO2 SMT3A SMT3H2
其他名称
Small ubiquitin-related modifier 2 (SUMO-2;HSMT3;SMT3 homolog 2;SUMO-3;Sentrin-2;Ubiquitin-like protein SMT3A;Smt3A)
Fields
>>Nucleocytoplasmic transport;>>Fluid shear stress and atherosclerosis
细胞定位
Nucleus. Nucleus, PML body.
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