免疫原
Synthesized peptide derived from human AFG3L2. at AA range: 744-793
特异性
AFG3L2 Polyclonal Antibody detects endogenous levels of AFG3L2
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000, ELISA 1:10000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008],
功能
cofactor:Binds 1 zinc ion per subunit .,function:Putative ATP-dependent protease.,similarity:In the C-terminal section; belongs to the peptidase M41 family.,similarity:In the N-terminal section; belongs to the AAA ATPase family.,tissue specificity:Ubiquitous.,
其他名称
AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)
Fields
>>Spinocerebellar ataxia
细胞定位
Mitochondrion . Mitochondrion inner membrane ; Multi-pass membrane protein .
组织表达
Ubiquitous. Highly expressed in the cerebellar Purkinje cells.
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