免疫原
Synthetic peptide from human protein at AA range: 141-190
特异性
The antibody detects endogenous CTGF
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009],
功能
function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer.,
基因名称（Gene Name）
CTGF CCN2 HCS24 IGFBP8
蛋白名称
Connective tissue growth factor (CCN family member 2) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)
其他名称
Connective tissue growth factor (CCN family member 2;Hypertrophic chondrocyte-specific protein 24;Insulin-like growth factor-binding protein 8;IBP-8;IGF-binding protein 8;IGFBP-8)
Fields
>>Apelin signaling pathway;>>Hippo signaling pathway
细胞定位
Secreted, extracellular space, extracellular matrix . Secreted .
组织表达
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
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