免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human PON1. AA range:51-100
特异性
The antibody detects endogenous PON1
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008],
功能
catalytic activity:A phenyl acetate + H(2)O = a phenol + acetate.,catalytic activity:An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.,disease:Genetic variation in PON1 is associated with susceptibility to diabetic retinopathy [MIM:612633]; also called microvascular complications of diabetes type 5 (MVCD5). Diabetic retinopathy is a major cause of blindness in diabetic patients. Retinal disease results from adverse effects on the blood vessels which supply the retina.,function:Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.,miscellaneous:The preferential ass
蛋白名称
Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)
其他名称
Serum paraoxonase/arylesterase 1 (PON 1;EC 3.1.1.2;EC 3.1.1.81;EC 3.1.8.1;Aromatic esterase 1;A-esterase 1;K-45;Serum aryldialkylphosphatase 1)
细胞定位
Secreted, extracellular space.
组织表达
Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
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