免疫原
The antiserum was produced against synthesized peptide derived from human HLA Class I. AA range:204-253
特异性
The antibody detects endogenous HLA Class I protein
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000, ELISA 1:10000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans
功能
function:Involved in the presentation of foreign antigens to the immune system.,polymorphism:The following alleles of A-1 are known: A*0101, A*0102, A*0103, A*0106 and A*0107. The sequence shown is that of A*0101.,polymorphism:The following alleles of A-11 are known: A*1101 (A-11E), A*1102 (A-11K), A*1103, A*1104, A*1105 and A*1107. The sequence shown is that of A*1101.,polymorphism:The following alleles of A-2 are known: A*0201, A*0202, A*0203, A*0204, A*0205, A*0206 (A2.4A), A*0207, A*0208, A*0209, A*0210, A*0211 (A2.5), A*0212, A*0213 (A*02SLU), A*0216, A*0217, A*0218 (A2K), A*0219, A*0220, A*0221, A*0231, A*0234 (A*AAT), A*0235, A*0236 and A*0237. The sequence shown is that of A*0201.,polymorphism:The following alleles of A-23 are known: A*2301, A*2302, A*2303, A*2304 and A*2305. The sequence shown is that of A*2301.,polymorphism:The following alleles of A-24 are known: A*2401, A*240
基因名称（Gene Name）
HLA-A HLAA
蛋白名称
major histocompatibility complex, class I
人蛋白质序列数据库
P01891/P01892/P04439/P05534/P10314/P10316/P13746/P16189/P18462/P30443/P30450/P30453/P30455/P30456/P30457/P30512/Q09160
细胞定位
Golgi membrane,endoplasmic reticulum,Golgi apparatus,Golgi medial cisterna,plasma membrane,integral component of plasma membrane,cell surface,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,
组织表达
A*3201,Blood,Brain,Buffy coat,Hematopoietic,Liver,Lung,Lymp
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