免疫原
Synthesized peptide derived from human EIF5 (Phospho-Ser389+Ser390)
特异性
This antibody detects endogenous levels of EIF5 (Phospho-Ser389+Ser390) at Human, Mouse,Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.200% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010],
功能
function:Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).,similarity:Belongs to the eIF-2-beta/eIF-5 family.,similarity:Contains 1 W2 domain.,
蛋白名称
EIF5 (Phospho-Ser389+Ser390)
其他名称
Eukaryotic translation initiation factor 5 (eIF-5)
细胞定位
nucleus,cytoplasm,cytosol,plasma membrane,cell-cell adherens junction,
组织表达
Brain,Epithelium,Lymph,Pooled,Uterus,
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