免疫原
Synthesized phosho peptide around human RanBP3 (Ser58)
特异性
This antibody detects endogenous levels of Human RanBP3 (phospho-Ser58)
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
功能
function:Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RanBD1 domain.,subunit:Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1.,tissue specificity:Widely expressed with high levels in testis and heart.,
其他名称
Ran-binding protein 3 (RanBP3)
Fields
>>Human T-cell leukemia virus 1 infection
细胞定位
Cytoplasm . Nucleus .
组织表达
Widely expressed with high levels in testis and heart.
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