免疫原
Synthesized peptide derived from human PAPAS AA range: 48-98
特异性
This antibody detects endogenous levels of PAPAS at Human
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1：50-200. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
catalytic activity:Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Present in serum and placenta during pregnancy; levels increase throughout pregnancy.,enzyme regulation:Inhibited by complexation with the proform of PRG2.,function:Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.,induction:By 8-bromoadenosine-3',5'-phosphate.,PTM:There appear to be no free sulfhydryl groups.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a
基因名称（Gene Name）
PAPPA-AS1 DIPAS PAPPAS
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达
Expressed in placenta with lower expression in brain, kidney and testis.
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