免疫原
Synthesized peptide derived from human URGCP AA range: 345-395
特异性
This antibody detects endogenous levels of URGCP at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008],
功能
function:May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.,induction:By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level).,sequence caution:Translation N-terminally extended.,subcellular location:In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.,tissue specificity:Strongly expressed in hepatitis B-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.,
基因名称（Gene Name）
URGCP KIAA1507 URG4
细胞定位
Cytoplasm . Nucleus . In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
组织表达
Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.
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