免疫原
Synthesized peptide derived from human RSLBA AA range: 68-118
特异性
This antibody detects endogenous levels of RSLBA at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景(Background)
RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008],
功能
developmental stage:Down-regulated during development of THP-1 monocytes into macrophages.,induction:Down-regulated by TGFB1.,similarity:Belongs to the small GTPase superfamily. Ras family.,tissue specificity:Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.,
细胞定位
Nucleus, nucleolus . Associates with rDNA transcription unit throughout the cell cycle. .
组织表达
Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.