免疫原
Synthesized peptide derived from human FBXL4 AA range: 396-446
特异性
This antibody detects endogenous levels of FBXL4 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
功能
similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,tissue specificity:Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.,
基因名称（Gene Name）
FBXL4 FBL4 FBL5
细胞定位
Cytoplasm. Nucleus. Mitochondrion.
组织表达
Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.
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