免疫原
Synthesized peptide derived from human ISG20 AA range: 87-137
特异性
This antibody detects endogenous levels of ISG20 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
catalytic activity:Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.,cofactor:Manganese.,function:Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.,induction:Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level.,miscellaneous:Stable and constitutive expression confers resistance to vesicular stomatitis virus (VSV), influenza virus, and encephalomyocarditis virus (EMCV) infection in HeLa cells, providing an alternative antiviral pathway against RNA genomic viruses. Up regulated by E2 in estrogen receptor-positive breast cancer lines.,similarity:Belongs to the exonucl
基因名称（Gene Name）
ISG20 HEM45
细胞定位
Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
组织表达
Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines.
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