免疫原
Synthesized peptide derived from human VPRBP AA range: 804-854
特异性
This antibody detects endogenous levels of VPRBP at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
domain:Although not canonical, the WD repeat-like region is related to WD repeats.,function:May act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 and arrest the cell cycle in G2 phase.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the VPRBP family.,similarity:Contains 1 LisH domain.,subunit:Interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex. In case of infection, interacts with HIV-1 virus Vpr protein and forms a ternary complex with HIV-1 Vpr and DDB1.,tissue specificity:Ubiquitously expressed.,
基因名称（Gene Name）
VPRBP DCAF1 KIAA0800 RIP
Fields
>>Human immunodeficiency virus 1 infection
细胞定位
Cytoplasm. Nucleus. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis.
组织表达
Ubiquitously expressed.
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