免疫原
Synthesized peptide derived from human ANO3 AA range: 518-568
特异性
This antibody detects endogenous levels of ANO3 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015],
功能
function:May act as a calcium-activated chloride channel.,similarity:Belongs to the anoctamin family.,
基因名称（Gene Name）
ANO3 C11orf25 TMEM16C GENX-3947
细胞定位
Cell membrane ; Multi-pass membrane protein . Shows an intracellular localization. .
组织表达
Highly expressed in the forebrain striatum.
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