免疫原
Synthesized peptide derived from human LLR1 AA range: 116-166
特异性
This antibody detects endogenous levels of LLR1 at Human
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011],
功能
function:May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 5 LRR (leucine-rich) repeats.,subunit:Interacts with the cytoplasmic domain of TNFRSF9. Component of the probable ECS(PPIL5) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and PPIL5. Interacts with CUL2, RBX1, TCEB1 and TCEB2.,tissue specificity:Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney.,
基因名称（Gene Name）
LRR1 PPIL5
组织表达
Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney.
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