免疫原
Synthesized peptide derived from human ANR11 AA range: 557-607
特异性
This antibody detects endogenous levels of ANR11 at Human
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:50-200. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景(Background)
This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012],
功能
function:May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 4 ANK repeats.,subunit:Interacts with the PAS region of the p160 coactivators.,
基因名称(Gene Name)
ANKRD11 ANCO1
细胞定位
Nucleus . Localizes to chromatin during prometaphase. .