免疫原
Synthesized peptide derived from human ERC2 AA range: 368-418
特异性
This antibody detects endogenous levels of ERC2 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.246% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015],
功能
function:Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,subcellular location:In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density.,subunit:Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A.,
基因名称（Gene Name）
ERC2 KIAA0378
细胞定位
Cytoplasm . Cell junction, synapse . Cell junction, synapse, presynaptic active zone . Cytoplasm, cytoskeleton . In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). .
组织表达
Brain,Epithelium,PNS,
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