免疫原
Synthesized peptide derived from human CSTN3 AA range: 660-710
特异性
This antibody detects endogenous levels of CSTN3 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.237% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
domain:Binds synaptic Ca(2+) with its cytoplasmic domain.,function:May modulate calcium-mediated postsynaptic signals (By similarity). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.,PTM:Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-beta chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with gamma-secretase.,similarity:Contains 2 cadh
基因名称（Gene Name）
CLSTN3 CS3 KIAA0726
其他名称
Calsyntenin-3 (Alcadein-beta) (Alc-beta)
细胞定位
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane . Golgi apparatus membrane . Cell junction, synapse, postsynapse . Cell projection, dendrite . Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. .
组织表达
According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern).
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