免疫原
Synthesized peptide derived from human MFN1 AA range: 163-213
特异性
This antibody detects endogenous levels of MFN1 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.12% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008],
功能
catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.,similarity:Belongs to the mitofusin family.,subunit:Forms homomultimers and heteromultimers with MFN2. Multimerization, which is probably mediated by the coiled coil region, may play an essential role in mitochondrion fusion (By similarity). Participates in a high molecular weight multiprotein complex.,tissue specificity:Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.,
其他名称
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
Fields
>>Mitophagy - animal;>>NOD-like receptor signaling pathway;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Mitochondrion outer membrane ; Multi-pass membrane protein .; [Isoform 2]: Cytoplasm .
组织表达
Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411).
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