免疫原
Synthesized peptide derived from part region of human protein
特异性
NOXA1 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
功能
developmental stage:Expressed in fetal kidney.,domain:The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.,domain:The TPR repeats mediate interaction with RAC1.,function:Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.,PTM:Interaction with YWHAZ depends on phosphorylation by PKA.,similarity:Belongs to the NCF2/NOXA1 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 4 TPR repeats.,subcellular location:Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric comple
基因名称（Gene Name）
NOXA1 P51NOX
蛋白名称
NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox)
细胞定位
Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
组织表达
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
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