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VPS11 Polyclonal Antibody

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BYab-07846

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;ELISA
分子量(DA)
103kD
免疫原
Synthesized peptide derived from part region of human protein
特异性
VPS11 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
功能
function:May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.,similarity:Belongs to the VPS11 family.,similarity:Contains 1 clathrin repeat.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.,subunit:Large hetero-oligomeric complex together with VPS16, VPS18 and VPS33A. Interacts with STX7.,tissue specificity:Ubiquitous. Expression was highest in heart and low in lung.,
基因名称(Gene Name)
VPS11 RNF108 PP3476
蛋白名称
Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)
简称
VPS11
其他名称
Fields
>>Salmonella infection
人基因ID
55823
人蛋白质序列数据库
Q9H270
小鼠基因ID
小鼠蛋白质序列数据库
Q91W86
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Endosome . Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome . Cytoplasmic vesicle . Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle, clathrin-coated vesicle .
组织表达
Ubiquitous. Expression was highest in heart and low in lung.
储存(Storage)
-20°C/1 year

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VPS11 Polyclonal Antibody

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