免疫原
Synthesized peptide derived from part region of human protein
特异性
GPR64 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
功能
function:Could be involved in a signal transduction pathway controlling epididymal function and male fertility.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit .,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,subunit:Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety.,tissue specificity:Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.,
基因名称（Gene Name）
GPR64 HE6 TM7LN2
蛋白名称
G-protein coupled receptor 64 (Human epididymis-specific protein 6) (He6)
细胞定位
Apical cell membrane ; Multi-pass membrane protein .
组织表达
Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.
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