欢迎访问南京博研生物官网 服务热线:025-52298998 |
您当前的位置: 首页 > 产品中心 > 一抗 > 多克隆抗体

PEAR1 Polyclonal Antibody

说明书

BYab-07159

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

产品简介 实验方案 引用文献 相关产品

产品简介>

宿主
反应性
应用
WB;ELISA
分子量(DA)
114kD
免疫原
Synthesized peptide derived from human protein . at AA range: 910-990
特异性
PEAR1 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008],
功能
function:When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.,PTM:Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.,similarity:Belongs to the MEGF family.,similarity:Contains 1 EMI domain.,similarity:Contains 9 EGF-like domains.,subcellular location:Detected on the cell surface in resting platelets.,subunit:Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.,tissue specificity:Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas
基因名称(Gene Name)
PEAR1 MEGF12
蛋白名称
Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)
简称
PEAR1
其他名称
Fields
人基因ID
375033
人蛋白质序列数据库
Q5VY43
小鼠基因ID
小鼠蛋白质序列数据库
Q8VIK5
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cell membrane ; Single-pass membrane protein . Detected on the cell surface in resting platelets. .
组织表达
Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.
储存(Storage)
-20°C/1 year

实验方案>

实验步骤

引用文献(0)>

相关产品>

成功添加到购物车

查看购物车 继续购物

PEAR1 Polyclonal Antibody

筛选器: All

亮暗模式切换
X

在线
客服

在线客服
09:00 - 18:00

服务热线

服务
热线

客服服务热线

025-52298998
客服服务热线

扫码

扫码
咨询

微信二维码 微信扫一扫立即咨询
返回顶部 顶部