免疫原
Synthesized peptide derived from part region of human protein
特异性
FKBP5 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009],
功能
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by FK506 but not cyclosporin.,function:Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.,induction:By androgen.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the FKBP-type PPIase family.,similarity:Contains 2 PPIase FKBP-type domains.,similarity:Contains 3 TPR repeats.,subunit:Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid.,tissue specificity:Widely expressed, enriched in testis compared to other tissues.,
基因名称（Gene Name）
FKBP5 AIG6 FKBP51
蛋白名称
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated
Fields
>>Estrogen signaling pathway
细胞定位
Cytoplasm . Nucleus .
组织表达
Widely expressed, enriched in testis compared to other tissues.
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