免疫原
Synthesized peptide derived from part region of human protein
特异性
MEP1B Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011],
功能
catalytic activity:Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the peptidase M12A family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 MAM domain.,similarity:Contains 1 MATH domain.,subunit:Homotetramer of alpha or beta subunits; heterotetramer of two alpha and two beta subunits are formed by non-covalent association of two disulfide-linked heterodimers.,
蛋白名称
Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta)
Fields
>>Protein digestion and absorption
细胞定位
Cell membrane ; Single-pass type I membrane protein. Secreted . Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. .
组织表达
The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
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