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SCRB2 Polyclonal Antibody

说明书

BYab-06902

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;ELISA
分子量(DA)
52kD
免疫原
Synthesized peptide derived from part region of human protein
特异性
SCRB2 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encod
功能
disease:Defects in SCARB2 are the cause of action myoclonus-renal failure syndrome (AMRF) [MIM:254900]; also known as myoclonus-nephropathy syndrome. AMRF is an autosomal recessive progressive myoclonic epilepsy associated with renal failure. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved.,function:May act as a lysosomal receptor.,mass spectrometry: PubMed:11840567,similarity:Belongs to the CD36 family.,
基因名称(Gene Name)
SCARB2 CD36L2 LIMPII
蛋白名称
Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36)
简称
SCRB2
其他名称
Fields
>>Lysosome
人基因ID
950
人蛋白质序列数据库
Q14108
小鼠基因ID
小鼠蛋白质序列数据库
O35114
大鼠基因ID
大鼠蛋白质序列数据库
P27615
细胞定位
Lysosome membrane ; Multi-pass membrane protein .
组织表达
Cerebellum,Eye,Liver,Mammary cancer,
储存(Storage)
-20°C/1 year

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SCRB2 Polyclonal Antibody

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