免疫原
Synthesized peptide derived from part region of human protein
特异性
BAMBI Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
BMP and activin membrane bound inhibitor(BAMBI) Homo sapiens This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008],
功能
developmental stage:Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.,function:Negatively regulates TGF-beta signaling.,similarity:Belongs to the BAMBI family.,tissue specificity:High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.,
基因名称（Gene Name）
BAMBI NMA
蛋白名称
BMP and activin membrane-bound inhibitor homolog (Non-metastatic gene A protein) (Putative transmembrane protein NMA)
Fields
>>Wnt signaling pathway;>>TGF-beta signaling pathway
细胞定位
Membrane ; Single-pass type I membrane protein .
组织表达
High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
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