免疫原
Synthesized peptide derived from part region of human protein
特异性
UBP6 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,disease:Involved in tumorigenesis.,function:Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.,miscellaneous:The USP6 gene only exists in the primate lineage.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Testis specific. Expressed in various cancer cell lines.,
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,disease:Involved in tumorigenesis.,function:Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.,miscellaneous:The USP6 gene only exists in the primate lineage.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Testis specific. Expressed in various cancer cell lines.,
基因名称（Gene Name）
USP6 HRP1 TRE2
蛋白名称
Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)
细胞定位
Cell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
组织表达
Testis specific. Expressed in various cancer cell lines.
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