免疫原
Synthesized peptide derived from part region of human protein
特异性
PP1RA Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012],
功能
function:Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.,PTM:Phosphorylated on Ser-398 and Thr-400 by PKA within the region necessary for interaction with PPP1CA.,similarity:Contains 1 C3H1-type zinc finger.,similarity:Contains 1 TFIIS N-terminal domain.,subcellular location:Found in discrete nucleoplasmic bodies and within nucleoli.,subunit:Interacts with PPP1CA and PPP1CC.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
基因名称（Gene Name）
PPP1R10 CAT53 FB19 PNUTS
蛋白名称
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (
细胞定位
Nucleus . Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). .
组织表达
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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