免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
MYO3A Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MYO3A are the cause of non-syndromic sensorineural deafness autosomal recessive type 30 (DFNB30) [MIM:607101]. DFNB30 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing.,similarity:Contains 1 myosin head-like domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 IQ domains.,similarity:In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.,tissue specificity:Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas.,
蛋白名称
Myosin-IIIa (EC 2.7.11.1)
细胞定位
Cytoplasm, cytoskeleton. Cytoplasm . Cell projection, filopodium tip . Cell projection, stereocilium . Increased localization at the filodium tip seen in the presence of MORN4. .
组织表达
Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas.
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