免疫原
Synthesized peptide derived from part region of human protein
特异性
HACE1 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016],
功能
developmental stage:Expressed in fetal and pediatric kidney cells.,function:E3 ubiquitin-protein ligase that may function in cellular proteins degradation.,induction:Down-regulated in sporadic Wilms tumor.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 6 ANK repeats.,subcellular location:A significant portion localizes to the endoplasmic reticulum.,subunit:Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.,tissue specificity:Expressed in multiple tissues including heart, brain and kidney.,
基因名称（Gene Name）
HACE1 KIAA1320
蛋白名称
E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1)
细胞定位
Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
组织表达
Expressed in multiple tissues including heart, brain and kidney.
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