分子量（DA）
human:85kD, Mouse 65-70kD
免疫原
Synthesized peptide derived from part region of human protein
特异性
CTSR1 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008],
功能
developmental stage:Expressed meiotically and poszt-meiotically.,function:Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.,induction:Down-regulated in patients lacking sperm motility.,similarity:Belongs to the cation channel sperm-associated family.,subunit:Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of a complex, at least composed of CATSPER1, HSPA1B and CATSPERB. Interacts with CATSPER3 and CATSPER4 (By similarity). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity.,tissue specificity:Testis-specific. Specifically present in the principal piece of spe
蛋白名称
Cation channel sperm-associated protein 1 (CatSper1) (hCatSper)
细胞定位
Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein . Specifically located in the principal piece of the sperm tail. .
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