免疫原
Synthesized peptide derived from human protein . at AA range: 720-800
特异性
ADA23 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
ADAM metallopeptidase domain 23(ADAM23) Homo sapiens This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013],
功能
developmental stage:Highly expressed in the fetal brain.,domain:A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.,function:May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,subunit:Ligand for integrin alpha-V/beta-3.,tissue specificity:Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.,
基因名称（Gene Name）
ADAM23 MDC3
蛋白名称
Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)
细胞定位
Cell membrane ; Single-pass type I membrane protein .; [Isoform Gamma]: Secreted.
组织表达
Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
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