免疫原
Synthesized peptide derived from human protein . at AA range: 650-730
特异性
SATB2 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010],
功能
disease:Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11).,disease:Defects in SATB2 are the cause of isolated cleft palate with mental retardation [MIM:119540]. Patients manifest cleft palate, craniofacial dysmorphism and profound mental retardation.,function:May play an important role in palate formation.,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 2 CUT DNA-binding domains.,tissue specificity:High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.,
基因名称（Gene Name）
SATB2 KIAA1034
蛋白名称
DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2)
组织表达
High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.
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