免疫原
Synthesized peptide derived from human protein . at AA range: 350-430
特异性
TNIK Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TRAF2 and NCK.,tissue specificity:Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle.,
基因名称（Gene Name）
TNIK KIAA0551
蛋白名称
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
细胞定位
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
组织表达
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
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