免疫原
Synthesized peptide derived from human protein . at AA range: 340-420
特异性
K1C9 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
keratin 9(KRT9) Homo sapiens This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008],
功能
caution:Was originally (PubMed:2140676) thought to be a 60 kDa chain of placental scatter protein.,disease:Defects in KRT9 are a cause of palmoplantar keratoderma epidermolytic (EPPK) [MIM:144200]; also abbreviated EHPPK. EPPK is a dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins.,disease:Knuckle pads are sometimes associated with EPPK [MIM:149100]. Knuckle pads consist of an autosomal dominant trait, in which thick pads of skin appear over the proximal phalangeal joints.,function:May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.,induction:Induced by intrinsic regulatory mechanisms and by extrinsic signals from a subset of derma
蛋白名称
Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)
Fields
>>Estrogen signaling pathway;>>Staphylococcus aureus infection
细胞定位
extracellular space,nucleus,intermediate filament,membrane,extracellular exosome,
组织表达
Expressed in the terminally differentiated epidermis of palms and soles.
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