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PPAR Delta mouse Monoclonal Antibody(2F9)

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BYab-04842

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
IF;IHC
分子量(DA)
50kD
免疫原
Recombinant Protein of PPAR Delta of PPAR Delta
特异性
PPAR Delta protein detects endogenous levels of PPAR Delta
来源
Monoclonal, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IF: 1:50-200 IHC 1:100-200
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
背景(Background)
peroxisome proliferator activated receptor delta(PPARD) Homo sapiens This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this
功能
function:Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand.,online information:Peroxisome proliferator-activated receptor entry,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer with the retinoid X receptor.,tissue specificity:Ubiquitous with maximal levels in placenta and skeletal muscle.,
基因名称(Gene Name)
PPARD NR1C2 PPARB
蛋白名称
PPAR Delta
简称
PPAR Delta
其他名称
Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
Fields
>>PPAR signaling pathway;>>Wnt signaling pathway;>>Pathways in cancer;>>Acute myeloid leukemia
人基因ID
5467
人蛋白质序列数据库
Q03181
小鼠基因ID
小鼠蛋白质序列数据库
P35396
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus.
组织表达
Ubiquitous with maximal levels in placenta and skeletal muscle.
储存(Storage)
-20°C/1 year

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PPAR Delta mouse Monoclonal Antibody(2F9)

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