免疫原
Purified recombinant human PP1C protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of PP1C and does not cross-react with related proteins.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,miscellaneous:Microcystin toxin is bound to Cys-273 through a thioether bond.,online information:The things we forget -Issue 32 of March 2003,similarity:Belon
其他名称
EC 3.1.3.16;PP 1G;PP-1G;PP1G;PP1G_HUMAN;PP1gamma;PPP 1G;PPP1CC;PPP1CC protein;PPP1G; Protein phosphatase 1 catalytic subunit gamma isoform;Protein phosphatase 1C catalytic subunit;Protein phosphatase 1C subunit;Protein phosphatase 2C gamma isoform; Serine/threonine phosphatase 1 gamma;Serine/threonine protein phosphatase PP1 gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.
Fields
>>mRNA surveillance pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Oocyte meiosis;>>Cellular senescence;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Hippo signaling pathway;>>Focal adhesion;>>Platelet activation;>>Long-term potentiation;>>Dopaminergic synapse;>>Inflammatory mediator regulation of TRP channels;>>Regulation of actin cytoskeleton;>>Insulin signaling pathway;>>Oxytocin signaling pathway;>>Insulin resistance;>>Amphetamine addiction;>>Alcoholism;>>Herpes simplex virus 1 infection;>>Proteoglycans in cancer;>>Diabetic cardiomyopathy
细胞定位
Cytoplasm . Nucleus. Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus speckle . Chromosome, centromere, kinetochore . Cleavage furrow . Midbody . Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center . Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at
组织表达
Embryonic kidney,Placenta,Skeletal muscle,
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