免疫原
The antiserum was produced against synthesized peptide derived from human ZP1. AA range:221-270
特异性
ZP1 Polyclonal Antibody detects endogenous levels of ZP1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014],
功能
domain:The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.,function:The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.,PTM:O-glycosylated.,PTM:Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.,similarity:Belongs to the ZP domain family. ZPB subfamily.,similarity:Contains 1 P-type (trefoil) domain.,similarity:Contains 1 ZP domain.,subunit:Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.,tissue specificity:Oocytes.,
蛋白名称
Zona pellucida sperm-binding protein 1
其他名称
ZP1; Zona pellucida sperm-binding protein 1; Zona pellucida glycoprotein 1; Zp-1
细胞定位
[Processed zona pellucida sperm-binding protein 1]: Zona pellucida .; Cell membrane ; Single-pass type I membrane protein .
组织表达
Expressed in oocytes (at protein level).
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