免疫原
The antiserum was produced against synthesized peptide derived from human SEPT1. AA range:181-230
特异性
Septin 1 Polyclonal Antibody detects endogenous levels of Septin 1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
septin 1(SEPT1) Homo sapiens This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012],
功能
function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subunit:May assemble into a multicomponent structure.,
其他名称
SEPT1; DIFF6; PNUTL3; Septin-1; LARP; Peanut-like protein 3; Serologically defined breast cancer antigen NY-BR-24
Fields
>>Bacterial invasion of epithelial cells
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.
组织表达
Expressed at high levels in lymphoid and hematopoietic tissues.
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