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Sclerostin Polyclonal Antibody

说明书

BYab-04188

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;ELISA;IHC
分子量(DA)
26kD
免疫原
Synthesized peptide derived from Sclerostin . at AA range: 130-210
特异性
Sclerostin Polyclonal Antibody detects endogenous levels of Sclerostin protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008],
功能
disease:A 52 kb deletion downstream of SOST results in SOST transcription suppression and is a cause of van Buchem disease (VBCH) [MIM:239100]; also known as hyperostosis corticalis generalisata. VBCH is an autosomal recessive sclerosing bone dysplasia characterized by endosteal hyperostosis of the mandible, skull, ribs, clavicles, and diaphyses of the long bones. Affected patients present a symmetrically increased thickness of bones, most frequently found as an enlarged jawbone, but also an enlargement of the skull, ribs, diaphysis of long bones, as well as tubular bones of hands and feet. The clinical consequence of increased thickness of the skull include facial nerve palsy causing hearing loss, visual problems, neurological pain, and, very rarely, blindness as a consequence of optic atrophy. Serum alkaline phosphatase levels are elevated.,disease:Defects in SOST are the cause of scle
基因名称(Gene Name)
SOST
蛋白名称
Sclerostin
简称
Sclerostin
其他名称
SOST; Sclerostin
Fields
>>Wnt signaling pathway;>>Parathyroid hormone synthesis, secretion and action
人基因ID
50964
人蛋白质序列数据库
Q9BQB4
小鼠基因ID
小鼠蛋白质序列数据库
Q99P68
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Secreted, extracellular space, extracellular matrix .
组织表达
Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).
储存(Storage)
-20°C/1 year

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Sclerostin Polyclonal Antibody

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