免疫原
The antiserum was produced against synthesized peptide derived from human MART-1. AA range:41-90
特异性
Melan-A Polyclonal Antibody detects endogenous levels of Melan-A protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
功能
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
蛋白名称
Melanoma antigen recognized by T-cells 1
其他名称
MLANA; MART1; Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A
细胞定位
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
组织表达
Expression is restricted to melanoma and melanocyte cell lines and retina.
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