免疫原
Synthesized peptide derived from the Internal region of human FUT2.
特异性
FUT2 Polyclonal Antibody detects endogenous levels of FUT2 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
功能
catalytic activity:GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.,disease:Genetic variation in FUT2 is associated with vitamin B12 plasma level quantitative trait locus type 1 (B12QTL1) [MIM:612542]. The plasma level of vitamin B12 is a modifiable quantitative trait associated with many diseases. Vitamin B12 found in meat and milk products is composed of corrin and cobalt rings and is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodege
蛋白名称
Galactoside 2-alpha-L-fucosyltransferase 2
其他名称
FUT2; SEC2; Galactoside 2-alpha-L-fucosyltransferase 2; Alpha(1; 2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; SE2; Secretor blood group alpha-2-fucosyltransferase; Secretor factor; Se
Fields
>>Glycosphingolipid biosynthesis - lacto and neolacto series;>>Glycosphingolipid biosynthesis - globo and isoglobo series;>>Metabolic pathways
细胞定位
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Membrane-bound form in trans cisternae of Golgi.
组织表达
Small intestine, colon and lung.
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