免疫原
The antiserum was produced against synthesized peptide derived from human Defensin alpha4. AA range:27-76
特异性
Defensin α4 Polyclonal Antibody detects endogenous levels of Defensin α4 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
defensin alpha 4(DEFA4) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014],
功能
function:Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.,similarity:Belongs to the alpha-defensin family.,subunit:Homodimer.,
蛋白名称
Neutrophil defensin 4
其他名称
DEFA4; DEF4; Neutrophil defensin 4; Defensin; alpha 4; HNP-4; HP-4
Fields
>>NOD-like receptor signaling pathway;>>Staphylococcus aureus infection;>>Transcriptional misregulation in cancer
细胞定位
Secreted . Cytoplasmic vesicle, secretory vesicle . Stored as mature peptide in neutrophil granules. .
组织表达
Expressed in neutrophils (at protein level) (PubMed:2843187, PubMed:2500436, PubMed:2501794). Expressed in bone marrow (PubMed:8469233).
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