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Cdc42EP5 Polyclonal Antibody

说明书

BYab-03754

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
22kD
免疫原
The antiserum was produced against synthesized peptide derived from human BORG3. AA range:1-50
特异性
Cdc42EP5 Polyclonal Antibody detects endogenous levels of Cdc42EP5 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013],
功能
domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.,
基因名称(Gene Name)
CDC42EP5
蛋白名称
Cdc42 effector protein 5
简称
Cdc42EP5
其他名称
CDC42EP5; BORG3; CEP5; Cdc42 effector protein 5; Binder of Rho GTPases 3
Fields
人基因ID
148170
人蛋白质序列数据库
Q6NZY7
小鼠基因ID
58804
小鼠蛋白质序列数据库
Q9Z0X0
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
组织表达
Bone,Pancreas,
储存(Storage)
-20°C/1 year

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Cdc42EP5 Polyclonal Antibody

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