免疫原
Synthesized peptide derived from ARF GAP3 . at AA range: 280-360
特异性
ARF GAP3 Polyclonal Antibody detects endogenous levels of ARF GAP3 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008],
功能
caution:Was originally (PubMed:10704287) termed ARFGAP1.,developmental stage:Expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. Expressed at lower level in spleen, heart, kidney and liver during development.,enzyme regulation:GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).,function:GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.,similarity:Contains 1 Arf-GAP domain.,subcellular location:Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.,tissue specificity:Widely expressed. Highest expression in endocrine glands (pancreas, pituary gland, salivary gland, and prostate) and testis with a much higher expression
蛋白名称
ADP-ribosylation factor GTPase-activating protein 3
其他名称
ARFGAP3; ARFGAP1; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3
细胞定位
Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
组织表达
Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.
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