免疫原
The antiserum was produced against synthesized peptide derived from human AKAP3. AA range:191-240
特异性
AKAP 110 Polyclonal Antibody detects endogenous levels of AKAP 110 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013],
功能
domain:RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,function:May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the AKAP110 family.,subcellular location:Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.,subunit:Interacts with ROPN1 AND ROPN1L.,tissue specificity:Testis specific; only expressed in spermatids.,
蛋白名称
A-kinase anchor protein 3
其他名称
AKAP3; AKAP110; SOB1; A-kinase anchor protein 3; AKAP-3; A-kinase anchor protein 110 kDa; AKAP 110; Cancer/testis antigen 82; CT82; Fibrous sheath protein of 95 kDa; FSP95; Fibrousheathin I; Fibrousheathin-1; Protein kinase A-anchoring prot
细胞定位
Cytoplasmic vesicle, secretory vesicle, acrosome . Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.
组织表达
Testis specific; only expressed in spermatids.
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