免疫原
Synthesized phosho peptide around human HSP90α (Thr5 and 7)
特异性
This antibody detects endogenous levels of Human Mouse Rat HSP90α (phospho-Thr5 or 7)
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
功能
caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
基因名称（Gene Name）
HSP90AA1 HSP90A HSPC1 HSPCA
其他名称
Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Renal carcinoma antigen NY-REN-38)
Fields
>>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
细胞定位
Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
组织表达
Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius
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